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KMID : 0617320020110010224
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Journal of Pharmacetical Sceiences Ewha Womans University
2002 Volume.11 No. 1 p.224 ~ p.227
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Inhibitory Effects of Natural Sesquiterpenoids lsolated from the Rhizomes of Curcuma zedoaria on Prostaglandin E_2 and Nitric Oxide Production
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Hong, Chae Hee
Noh, Min Soo/Lee, Woo Young/Lee, Sang Kook
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Abstract
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β-Turmerone and ar-turmerone, sesquiterpenoids isolated from the rhizome of Curcuma zedoaria, inhibited lipopolysaccharide (LPS)-induced prostaglaandin E_2 production in cultured mouse macrophage cell RAW 264.7 in a dose-dependent manner (IC_50 = 7.3 μM for β-turmerone; IC_50 = 24.0 μM for ar-turmerone). In addition, thess compounds exhibited inhibitory effects on LPS-in-duced nitric oxide production in the cell system.
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